Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.

PloS one - 23 Aug 2010

Nantajit Danupon, Fan Ming, Duru Nadire, Wen Yunfei, Reed John C, Li Jian Jian

Abstract excerpt

The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical question in radiation therapy for the 50% human cancers with intact p53 function. Herein, we reveal an anti-apoptotic role of mitochondrial p53 regulated by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDC2 Protein Kinase

Share to Cell Survival

Share to Cyclin B1

Share to Membrane Potential, Mitochondrial

Share to Serine

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 20808790
DOI: 10.1371/journal.pone.0012341
PMCID: PMC2925892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.PMID 20808790Read ↗

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer diseaseSemantic proximity Read ↗

Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft modelSemantic proximity Read ↗

Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after.Semantic proximity Read ↗

Role of p53 mutations in the radiosensitivity status of tumor cells.Semantic proximity Read ↗

Mitochondrial death functions of p53Semantic proximity Read ↗

Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.Semantic proximity Read ↗

Targeting p53 to mitochondria for cancer therapySemantic proximity Read ↗

Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related CancersSemantic proximity Read ↗

The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53.Semantic proximity Read ↗

Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent PathwaysSemantic proximity Read ↗

Cyclin D1 Determines Mitochondrial Function InVivoSemantic proximity Read ↗

Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.