Article
Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model.
Cancer gene therapy - 1 Aug 2006
Zhu D-E, Höti N, Song Z, Jin L, Wu Z, Wu Q, Wu M
Abstract excerpt
Survivin (SVV), an inhibitor of apoptosis protein, is found to be upregulated in many cancers. We previously demonstrated that a dominant-negative mutant SVV-D53A was able to induce apoptosis in a p53-independent manner. Here, we report the construction and characterization of a recombinant replication-deficient adenoviral vector encoding a human SVV-D53A gene for its effectiveness against tumor growth both in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.