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Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1

21 Aug 2008

Abstract excerpt

The mechanisms by which quiescent cells, including adult stem cells, preserve their ability to resume proliferation after weeks or even years of cell cycle arrest are not known. We report that reversibility is not a passive property of nondividing cells, because enforced cell cycle arrest for a period as brief as 4 days initiates spontaneous, premature, and irreversible senescence. Increased expression of the...

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PMID: 18719287
DOI: 10.1126/science.1155998

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