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Stem Cell Quiescence

19 May 2011

Abstract excerpt

Adult stem cells are maintained in a quiescent state but are able to exit quiescence and rapidly expand and differentiate in response to stress. The quiescent state appears to be necessary for preserving the self-renewal of stem cells and is a critical factor in the resistance of cancer stem cells (CSCs) to chemotherapy and targeted therapies. Limited knowledge about quiescence mechanisms has prevented...

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PMID: 21593194
DOI: 10.1158/1078-0432.ccr-10-1499

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