Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells

6 Feb 2006

Abstract excerpt

Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with the intrinsic control of the number of cell divisions in human somatic tissues by a mechanism called replicative senescence. Replicative immortality is acquired by inactivation of p53 and p16INK4a genes and reactivation of hTERT gene expression. It is unknown whether the cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to RNA modifications and cancer
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16461895
DOI: 10.1073/pnas.0510877103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reprogramming of replicative senescence in hepatocellular carcinoma-derived cellsPMID 16461895Read ↗

Is Senescence Reversible?Semantic proximity Read ↗

CREG1 enhances p16 INK4a -induced cellular senescenceSemantic proximity Read ↗

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.Semantic proximity Read ↗

Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular CarcinogenesisSemantic proximity Read ↗

Therapeutic targeting of replicative immortalitySemantic proximity Read ↗

Identification of genes involved in reprogramming-induced senescenceSemantic proximity Read ↗

Hepatocellular carcinoma evades RB1-induced senescence by activating the FOXM1–FOXO1 axisSemantic proximity Read ↗

Real‐time imaging of transcriptional activation in live cells reveals rapid up‐regulation of the cyclin‐dependent kinase inhibitor gene CDKN1A in replicative cellular senescenceSemantic proximity Read ↗

Immortalization and Transformation of Human CellsSemantic proximity Read ↗

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.Semantic proximity Read ↗

Human embryonic stem cells: mechanisms to escape replicative senescence?Semantic proximity Read ↗

Cellular Model of p21-Induced Senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.