Article

Quiescence Induction Triggers Acute Accumulation of DNA Double-Strand Breaks That Drive Quiescence Heterogeneity

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> DNA double-strand breaks (DSBs) represent one of the most serious threats to genome integrity. Endogenous DSBs chiefly arise from cell cycle activities such as DNA replication and division, while dormant, non-proliferative cells are generally considered protected from such damage. Here we report that induction of quiescence by growth restriction in human retinal pigment epithelial (RPE) cells un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c97d3719-5888-5aab-bdbe-44dfcd745947
DOI: 10.1101/2025.09.24.678365

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quiescence Induction Triggers Acute Accumulation of DNA Double-Strand Breaks That Drive Quiescence HeterogeneityDOI 10.1101/2025.09.24.678365Read

From rest to repair: Safeguarding genomic integrity in quiescent cellsSemantic proximity Read

Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profileSemantic proximity Read

The role of cellular quiescence in cancer – beyond a quiet passengerSemantic proximity Read

Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastomaSemantic proximity Read

Genome Stability under Silence: DNA Repair Networks in Quiescent Fission YeastSemantic proximity Read

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activationSemantic proximity Read

Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1Semantic proximity Read

p53-dependent polyploidisation after DNA damage in G2 phaseSemantic proximity Read

CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawalSemantic proximity Read

The Hammer and the Dance of Cell Cycle ControlSemantic proximity Read

Quiescence Entry, Maintenance, and Exit in Adult Stem CellsSemantic proximity Read

Long-Term Quiescent Fibroblast Cells Transit into SenescenceSemantic proximity Read