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Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilities

2025-01-25

Abstract excerpt

<h4>SUMMARY</h4> Quiescence, a reversible state of cell-cycle arrest, is an adaptive feature of many adult tissue stem cells, including those in the adult brain. In gliomas, brain tumour stem cells that reside in a quiescent state preferentially survive chemotherapy and radiotherapy, highlighting their critical role in therapy resistance and disease progression. To date, it remains unclear whether the molecular p...

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Literature Corpus work
b5be6827-3bc1-5875-984d-4fb145f7700a
DOI
10.1101/2025.01.22.634421
Open publication

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Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilitiesDOI 10.1101/2025.01.22.634421
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