Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of cellular quiescence on the success of targeted CML therapy.

PloS one - 3 Oct 2007

Komarova Natalia L, Wodarz Dominik

Abstract excerpt

BACKGROUND: Similar to tissue stem cells, primitive tumor cells in chronic myelogenous leukemia have been observed to undergo quiescence; that is, the cells can temporarily stop dividing. Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targeted small molecule inhibitors. METHODS AND RESULTS: According to the models, the initiation of treatment can result...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Combined Modality Therapy
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Medical Oncology

Share to Piperazines

Share to Probability

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 17912367
DOI: 10.1371/journal.pone.0000990
PMCID: PMC1991595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of cellular quiescence on the success of targeted CML therapy.PMID 17912367Read ↗

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolutionSemantic proximity Read ↗

Drug resistance in cancer: Principles of emergence and preventionSemantic proximity Read ↗

The role of cellular quiescence in cancer – beyond a quiet passengerSemantic proximity Read ↗

Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilitiesSemantic proximity Read ↗

Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter?Semantic proximity Read ↗

Why Therapeutic Response May Not Prolong the Life of a Cancer Patient: Selection for Oncogenic ResistanceSemantic proximity Read ↗

Identifying Strong Modulators of Cellular Quiescence Depth Across Different Quiescent Cells and ConditionsSemantic proximity Read ↗

Concise Review: Cancer Cells Escape from Oncogene Addiction: Understanding the Mechanisms Behind Treatment Failure for More Effective TargetingSemantic proximity Read ↗

Successful Therapy Must Eradicate Cancer Stem CellsSemantic proximity Read ↗

Mechanisms of Cancer Cell Dormancy—Another Hallmark of Cancer?Semantic proximity Read ↗

Drug-induced colorectal cancer persister cells show increased mutation rateSemantic proximity Read ↗

Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of SignificanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.