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Article

A New Description of Cellular Quiescence

1 Mar 2006

Abstract excerpt

Cellular quiescence, defined as reversible growth/proliferation arrest, is thought to represent a homogenous state induced by diverse anti-mitogenic signals. We used transcriptional profiling to characterize human diploid fibroblasts that exited the cell cycle after exposure to three independent signals--mitogen withdrawal, contact inhibition, and loss of adhesion. We show here that each signal caused regulation...

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PMID: 16509772
DOI: 10.1371/journal.pbio.0040083

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