Article
The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae.
Genetics - 1 Oct 2008
Patterson Erin E, Fox Catherine A
Abstract excerpt
Sir1 establishes transcriptional silencing at the cryptic mating-type loci HMR and HML (HM loci) by recruiting the three other Sir proteins, Sir2, -3, and -4, that function directly in silenced chromatin. However, SIR1-independent mechanisms also contribute to recruiting the Sir2-4 proteins to the HM loci. A screen to elucidate SIR1-independent mechanisms that establish HMR silencing identified a mutation in...
Topics
- Cell Cycle
- Cell Cycle Proteins
- Chromatin Immunoprecipitation
- Cyclin B
- DNA-Binding Proteins
- Forkhead Transcription Factors
- Gene Expression Regulation, Fungal
- Gene Silencing
- Genes, Fungal
- Genes, Mating Type, Fungal
- Mutation