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Article

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children.

Blood - 15 Nov 2008

Atkinson Sarah H, Rockett Kirk A, Morgan Gareth, Bejon Philip A, Sirugo Giorgio, O'Connell Maria A, Hanchard Neil, Kwiatkowski Dominic P, Prentice Andrew M

Abstract excerpt

Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. This study investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes across the major histocompatibility complex (MHC) class III region, including TNF and its immediate neighbors nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18716131
DOI: 10.1182/blood-2008-06-162008
PMCID: PMC2581977

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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