Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

doi:10.1086/314533

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Article

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

The Journal of infectious diseases - 1 Jan 1999

McGuire W, Knight J C, Hill A V, Allsopp C E, Greenwood B M, Kwiatkowski D

Abstract excerpt

Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels f...

Topics

Alleles
Anemia
Base Sequence
Case-Control Studies
Child
Child, Preschool
DNA Primers
Gambia
HLA Antigens
Humans
Malaria, Cerebral
Malaria, Falciparum
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha

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Open in PubMed

Identifiers

PMID: 9841857
DOI: 10.1086/314533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9841857-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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