Article
Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX.
Genetic epidemiology - 1 Nov 2001
Aidoo M, McElroy P D, Kolczak M S, Terlouw D J, ter Kuile F O, Nahlen B, Lal A A, Udhayakumar V
Abstract excerpt
A polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene, with a guanine to adenine nucleotide change at position -308, TNF2 is associated with increased TNF-alpha production. TNF2 homozygotes have a higher risk of severe disease and/or death due to cerebral malaria and other infectious diseases. We investigated the impact of this allele on malaria morbidity and mortality in young...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.