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Article

Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria.

Acta tropica - 1 Sept 2016

Olaniyan Subulade A, Amodu Olukemi K, Bakare Adekunle A, Troye-Blomberg Marita, Omotade Olayemi O, Rockett Kirk A

Abstract excerpt

Tumour necrosis factor (TNF) - α has been shown to play an important role in the pathogenesis of falciparum malaria. Two TNF promoter polymorphisms, TNF-308 and TNF-238 have been associated with differential activity and production of TNF. In order to investigate the association between TNF-308 and TNF-238 and the clinical outcome of malaria in a Nigerian population, the two TNF polymorphisms were analysed using...

Topics

Adolescent
Child
Child, Preschool
Female
Genetic Predisposition to Disease
Genotype
Humans
Infant
Malaria, Cerebral
Malaria, Falciparum
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nigeria

Polymorphism, Genetic

Promoter Regions, Genetic

Severity of Illness Index

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 27178813
DOI: 10.1016/j.actatropica.2016.05.006

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria.PMID 27178813Read ↗

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TNF-α 238 Alleles Polymorphism and its Association With TNF-α Levels in the Severe Malaria Anemia Among Sudanese ChildrenSemantic proximity Read ↗

TNF-α 238 Alleles Polymorphism and its Association with TNF-α Levels in the Severe Malaria Anemia among Sudanese ChildrenSemantic proximity Read ↗

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