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Article

Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2009

Yerges Laura M, Zhang Yingze, Cauley Jane A, Kammerer Candace M, Nestlerode Cara S, Wheeler Victor W, Patrick Alan L, Bunker Clareann H, Moffett Susan P, Ferrell Robert E, Zmuda Joseph M

Abstract excerpt

WNT signaling is an important determinant of bone formation. The WNT co-receptor, Frizzled homolog 1 (FZD1), initiates WNT signal transduction. To study the influence of FZD1 genetic variation on measures of bone health, we first sequenced a 6.8-kb region surrounding FZD1 in 48 samples of African ancestry. We genotyped all common polymorphisms and performed association analysis with bone phenotypes in a larger...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18715140
DOI: 10.1359/jbmr.080816
PMCID: PMC2689083

Genes

FZD1
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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