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Article

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004

Loughlin John, Dowling Barbara, Chapman Kay, Marcelline Lucy, Mustafa Zehra, Southam Lorraine, Ferreira Athena, Ciesielski Cathleen, Carson Dennis A, Corr Maripat

Abstract excerpt

Osteoarthritis (OA) is a leading cause of disability in Western society with multiple risk factors, including a complex genetic pattern. Identifying loci involved in the heredity of OA might lead to insights into the molecular pathogenesis of this common disorder. A previous genome scan mapped a...

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Identifiers

PMID: 15210948
DOI: 10.1073/pnas.0403456101
PMCID: PMC470747

Genes

FRZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15210948-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.PMID 15210948Read ↗

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Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.Semantic proximity Read ↗

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