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Article

Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2008

Sims Anne-Marie, Shephard Neil, Carter Kim, Doan Tracy, Dowling Alison, Duncan Emma L, Eisman John, Jones Graeme, Nicholson Geoffrey, Prince Richard, Seeman Ego, Thomas Gethin, Wass John A, Brown Matthew A

Abstract excerpt

UNLABELLED: Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. INTRODUCTION: Although the high heritability of BMD variation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18021006
DOI: 10.1359/jbmr.071113

Genes

DKK2
LRP1
LRP5
LRP6
SFRP1
SOST
DKK1
FZD7
MAF
SFRP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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