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Article

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2009

Steer Colin D, Emmett Pauline M, Lewis Sarah J, Smith George Davey, Tobias Jon H

Abstract excerpt

The C677T MTHFR polymorphism has been associated with lumbar spine and hip BMD. In older adults, the genetic effect has been reported in women only. However, in younger adults, this influence may only be present in men. This study is the first to investigate associations between the C677T MTHFR polymorphism and bone phenotypes in children. Regression analyses were used to study the relationship between MTHFR...

Topics

Alleles
Bone Density
Child
Female
Genotype
Homocysteine
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Models, Genetic
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Puberty

Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 18715139
DOI: 10.1359/jbmr.080814
PMCID: PMC2742728

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18715139-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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