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Article

Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density.

Bone - 1 Oct 2004

Macdonald H M, McGuigan F E, Fraser W D, New S A, Ralston S H, Reid D M

Abstract excerpt

Bone mineral density is a complex trait regulated by an interaction between genetic and environmental factors. Recent studies have identified a functional polymorphism affecting codon 677 of the methylenetetrahydrofolate reductase (MTHFR) gene that is associated with reduced bone mineral density (BMD) in Japanese and Danish postmenopausal women and increased risk of fracture in elderly Danish women. Since dietary...

Topics

Biomarkers
Bone Density
Female
Follow-Up Studies
Genotype
Homocysteine
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Genetic
Riboflavin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15454103
DOI: 10.1016/j.bone.2004.05.018

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15454103-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density.PMID 15454103Read ↗

Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study.Semantic proximity Read ↗

Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.Semantic proximity Read ↗

Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.Semantic proximity Read ↗

Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.Semantic proximity Read ↗

The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women.Semantic proximity Read ↗

A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study.Semantic proximity Read ↗

Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis.Semantic proximity Read ↗

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women.Semantic proximity Read ↗

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Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.Semantic proximity Read ↗

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