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Article

Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study.

Bone - 1 Mar 2011

te Winkel M L, de Muinck Keizer-Schrama S M P F, de Jonge R, van Beek R D, van der Sluis I M, Hop W C J, Pieters R, van den Heuvel-Eibrink M M

Abstract excerpt

BACKGROUND: This study aims to identify folate-metabolism-related genetic risk factors for low bone mineral density (BMD) during/after pediatric acute lymphoblastic leukemia (ALL) treatment. PATIENTS AND METHODS: We investigated the influence of methylenetetrahydrofolate reductase (MTHFR 677C > T and 1298A > C) and methionine synthase reductase (MTRR 66A > G) single nucleotide polymorphisms (SNPs) on total body...

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Source

Identifiers

PMID: 20955826
DOI: 10.1016/j.bone.2010.10.163

Genes

MTHFR
SDS
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study.PMID 20955826Read ↗

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