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Article

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

7 Oct 2011

Abstract excerpt

Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells. Whilst in myeloid cells IRF8 is known to modulate growth and differentiation, the role of IRF4 is poorly understood. In this study, we show that IRF4 has activities similar to IRF8 in regulating myeloid cell...

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PMID: 22003407
DOI: 10.1371/journal.pone.0025812

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