Function and mechanism by which interferon regulatory factor-1 inhibits oncogenesis

doi:10.3892/ol.2012.1051

Article

Function and mechanism by which interferon regulatory factor-1 inhibits oncogenesis

28 Nov 2012

Abstract excerpt

The present review focuses on recent advances in the understanding of the molecular mechnisms by which interferon regulatory factor (IRF)-1 inhibits oncogenesis. IRF-1 is associated with regulation of interferon α and β transcription. In addition, numerous clinical studies have indicated that IRF-1 gene deletion or rearrangement correlates with development of specific forms of human cancer. IRF-1 has been...

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