Article
Interferon regulatory factor family of transcription factors and regulation of oncogenesis.
Cancer science - 1 Mar 2008
Takaoka Akinori, Tamura Tomohiko, Taniguchi Tadatsugu
Abstract excerpt
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)-alpha/beta system. The IRF family has now expanded to nine members, and gene-disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor...
Topics
- Animals
- Evolution, Molecular
- Humans
- Interferon Regulatory Factors
- Mutation
- Neoplasms
- Oncogene Proteins
- Signal Transduction
- Transcription Factors