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Article

IRF4 mutations in chronic lymphocytic leukemia

27 Jul 2011

Abstract excerpt

Interferon regulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription factors and has been shown to have critical functions at several stages of B-cell development. Genome-wide association study identified a polymorphism in the 3' untranslated region of IRF4 as a chronic lymphocytic leukemia risk locus. In this study, we report a recurrent heterozygous somatic mutation in...

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PMID: 21791429
DOI: 10.1182/blood-2011-04-350579

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