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Article

Implication of IRF4 Aberrant Gene Expression in the Acute Leukemias of Childhood

15 Aug 2013

Abstract excerpt

The most frequent targets of genetic alterations in human leukemias are transcription factor genes with essential functions in normal blood cell development. The Interferon Regulatory Factor 4 (IRF4) gene encodes a transcription factor important for key developmental stages of hematopoiesis, with known oncogenic implications in multiple myeloma, adult leukemias and lymphomas. Very few studies have reported an...

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PMID: 23977280
DOI: 10.1371/journal.pone.0072326

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