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Article

KLF4 suppresses transformation of pre-B cells by ABL oncogenes

5 Sept 2006

Abstract excerpt

Genes that are strongly repressed after B-cell activation are candidates for being inactivated, mutated, or repressed in B-cell malignancies. Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias. The human KLF4 gene has been identified as a tumor suppressor gene in colon and gastric cancer; in...

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PMID: 16954505
DOI: 10.1182/blood-2006-03-011106

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