Article

Human CSB-deficient iPSCs exhibit impaired DNA damage repair and stress responses following BPDE exposure in an early developmental model

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> Maintenance of genome integrity is essential for normal human development, particularly during pre-gastrulation stages when rapid proliferation and intense transcriptional activity increase susceptibility to DNA damage. Environmental genotoxins such as benzo[a]pyrene (BaP), a widespread polycyclic aromatic hydrocarbon, and its reactive metabolite benzo[a]pyrene diol epoxide (BPDE) form bulky DNA...

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Literature Corpus work: f590479c-2fef-5a07-a14b-824f952c70fe
DOI: 10.64898/2025.12.02.691678

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