Article
Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2007
van Minkelen Rick, de Visser Marieke C H, Houwing-Duistermaat Jeanine J, Vos Hans L, Bertina Rogier M, Rosendaal Frits R
Abstract excerpt
OBJECTIVE: It has been suggested that the overall effect of the major proinflammatory cytokine interleukin-1 (IL-1) on coagulation and fibrinolysis is prothrombotic. The aim of this study was to investigate whether common variations in IL1B, IL1RN, IL1R1, and IL1R2 influence the risk of venous thrombosis. METHODS AND RESULTS: In a case-control study on the causes of deep venous thrombosis, the Leiden...
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