Article
Huntingtin interacting protein 1 can regulate neurogenesis in Drosophila.
The European journal of neuroscience - 1 Aug 2008
Moores Justin N, Roy Sophie, Nicholson Donald W, Staveley Brian E
Abstract excerpt
Huntington's disease (HD) is associated with a range of cellular consequences including selective neuronal death and decreased levels of neurogenesis. Ultimately, these altered processes are dependent upon proteins that interact with Huntingtin (Htt) such as the Huntingtin-interacting protein 1 (Hip1) which has a reduced binding preference to expanded Htt. These effects are similar to those observed with modified...
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