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Article

Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.

Cancer research - 15 Feb 2008

Graves Chiron W, Philips Steven T, Bradley Sarah V, Oravecz-Wilson Katherine I, Li Lina, Gauvin Alice, Ross Theodora S

Abstract excerpt

Huntingtin interacting protein 1 (HIP1) is a 116-kDa endocytic protein, which is necessary for the maintenance of several tissues in vivo as its deficiency leads to degenerative adult phenotypes. HIP1 deficiency also inhibits prostate tumor progression in mice. To better understand how deficiency of HIP1 leads to such phenotypes, we analyzed tumorigenic potential in mice homozygous for a Hip1 mutant allele,...

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Source

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Identifiers

PMID: 18281481
DOI: 10.1158/0008-5472.CAN-07-5892
PMCID: PMC3135020

Genes

HIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.PMID 18281481Read ↗

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Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.Semantic proximity Read ↗

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

HIP1 mediates oncogenic transformation and cancer progression through STAT3 signallingSemantic proximity Read ↗

Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.Semantic proximity Read ↗

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.Semantic proximity Read ↗

Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor.Semantic proximity Read ↗

Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.Semantic proximity Read ↗

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice.Semantic proximity Read ↗

Deficiency of the Endocytic Protein <i>Hip1</i> Leads to Decreased <i>Gdpd3</i> expression, Low Phosphocholine, and KypholordosisSemantic proximity Read ↗

Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung AdenocarcinomaSemantic proximity Read ↗

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