Article

Daughterless, the <i>Drosophila</i> orthologue of TCF4, is required for associative learning and maintenance of synaptic proteome

2019-10-03

Abstract excerpt

Mammalian Transcription Factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities like Pitt-Hopkins syndrome (PTHS). Here we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed in the Drosophila brain structures associated with learning and memory, the mushroom bodies. Furthermore, silencing of da in mushroom body neurons impairs appetitive associative...

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Literature Corpus work: 228c2f5e-8b83-50e4-a11f-655d35042194
DOI: 10.1101/792796

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