Article
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics - 1 Nov 2002
Singaraja Roshni R, Hadano Shinji, Metzler Martina, Givan Scott, Wellington Cheryl L, Warby Simon, Yanai Anat, Gutekunst Claire-Anne, Leavitt Blair R, Yi Hong, Fichter Keith, Gan Lu, McCutcheon Krista, Chopra Vikramjit, Michel Jennifer, Hersch Steven M, Ikeda Joh-E, Hayden Michael R
Abstract excerpt
Huntington disease (HD) is caused by polyglutamine [poly(Q)] expansion in the protein huntingtin (htt). Although the exact mechanism of disease progression remains to be elucidated, altered interactions of mutant htt with its protein partners could contribute to the disease. Using the yeast two-hybrid system, we have isolated a novel htt interacting protein, HIP14. HIP14's interaction with htt is inversely...
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