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Article

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Oct 2007

Parker J Alex, Metzler Martina, Georgiou John, Mage Marilyne, Roder John C, Rose Ann M, Hayden Michael R, Néri Christian

Abstract excerpt

Huntingtin-interacting protein 1 (HIP1) was identified through its interaction with htt (huntingtin), the Huntington's disease (HD) protein. HIP1 is an endocytic protein that influences transport and function of AMPA and NMDA receptors in the brain. However, little is known about its contribution to neuronal dysfunction in HD. We report that the Caenorhabditis elegans HIP1 homolog hipr-1 modulates presynaptic...

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Identifiers

PMID: 17928447
DOI: 10.1523/JNEUROSCI.1941-07.2007
PMCID: PMC6672856

Genes

HIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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