Article
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses.
PloS one - 13 Aug 2008
Plagnol Vincent, Uz Elif, Wallace Chris, Stevens Helen, Clayton David, Ozcelik Tayfun, Todd John A
Abstract excerpt
Lymphoblastoid cell lines (LCL) are being actively and extensively used to examine the expression of specific genes and genome-wide expression profiles, including allele specific expression assays. However, it has recently been shown that approximately 10% of human genes exhibit random patterns of monoallelic expression within single clones of LCLs. Consequently allelic imbalance studies could be significantly...
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