Article

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age

1996-07-01

Abstract excerpt

Abstract The utility of X-inactivation based clonality assays for evaluation of human neoplasia is well-documented. However, excessive Lyonization is a potential limitation of these assays, because it mimics clonal derivation of cells. The incidence of excessive Lyonization in healthy females is controversial, with reported incidence varying from 4% to 33%. Several explanations have been offered for the observed v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bdfefb5-affe-5877-9318-8e36ce19a173
DOI: 10.1182/blood.v88.1.59.59

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with ageDOI 10.1182/blood.v88.1.59.59Read

X-linked clonality testing: interpretation and limitationsSemantic proximity Read

Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach.Semantic proximity Read

The dynamics of X‐inactivation skewing as women ageSemantic proximity Read

Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis.Semantic proximity Read

60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.Semantic proximity Read

Clonality analysis using X-chromosome inactivation patterns by HUMARA-PCR assay in female controls and patients with idiopathic thrombocytosis in Taiwan.Semantic proximity Read

Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromesSemantic proximity Read

Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay.Semantic proximity Read

Skewed X inactivation in healthy individuals and in different diseasesSemantic proximity Read

Assessment of mechanism of acquired skewed X inactivation by analysis of twins.Semantic proximity Read

Genetic drivers and cellular selection of female mosaic X chromosome loss.Semantic proximity Read

G6PD deficiency from lyonization after hematopoietic stem cell transplantation from female heterozygous donors.Semantic proximity Read