Article
Evidence for limited molecular genetic heterogeneity as defined by allelotyping and clonal analysis in nine metastatic breast carcinomas.
Cancer research - 15 Aug 1993
Bonsing B A, Devilee P, Cleton-Jansen A M, Kuipers-Dijkshoorn N, Fleuren G J, Cornelisse C J
Abstract excerpt
To investigate genetic intratumor heterogeneity, 42 samples of nine primary breast carcinomas and 29 related lymph node metastases were examined for DNA ploidy status, allelotype, and X chromosome inactivation pattern. Two primary breast carcinomas showed DNA index heterogeneity and five containe...
Topics
- Adult
- Aged
- Alleles
- Autoradiography
- Blotting, Southern
- Breast Neoplasms
- DNA, Neoplasm
- Dosage Compensation, Genetic
- Female
- Flow Cytometry
- Humans
- Lymphatic Metastasis
- Middle Aged
- Ploidies
- Polymorphism, Restriction Fragment Length