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Article

Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.

Oncotarget - 27 Sept 2016

Quentmeier Hilmar, Pommerenke Claudia, Ammerpohl Ole, Geffers Robert, Hauer Vivien, MacLeod Roderick A F, Nagel Stefan, Romani Julia, Rosati Emanuela, Rosén Anders, Uphoff Cord C, Zaborski Margarete, Drexler Hans G

Abstract excerpt

Genetic heterogeneity though common in tumors has been rarely documented in cell lines. To examine how often B-lymphoma cell lines are comprised of subclones, we performed immunoglobulin (IG) heavy chain hypermutation analysis. Revealing that subclones are not rare in B-cell lymphoma cell lines, 6/49 IG hypermutated cell lines (12%) consisted of subclones with individual IG mutations. Subclones were also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27566572
DOI: 10.18632/oncotarget.11524
PMCID: PMC5325377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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