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Article

Generation of a conditional mutant allele for Tab1 in mouse.

Genesis (New York, N.Y. : 2000) - 1 Aug 2008

Inagaki Maiko, Komatsu Yoshihiro, Scott Greg, Yamada Gen, Ray Manas, Ninomiya-Tsuji Jun, Mishina Yuji

Abstract excerpt

TAK1 binding protein 1 (TAB1) binds and induces autophosphorylation of TGF-beta activating kinase (TAK1). TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. Conventional disruption of the murine Tab1 gene results in late gestational lethality showing...

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Source

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Identifiers

PMID: 18693278
DOI: 10.1002/dvg.20418
PMCID: PMC2637350

Genes

TAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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