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Article

TAK1 mediates BMP signaling in cartilage

1 Apr 2010

Abstract excerpt

Although many signals are capable of activating MAPK signaling cascades in chondrocytes in vitro, the function of these pathways remains unclear in vivo. Here we report the phenotype of mice with a conditional deletion of TGF-beta-activated kinase 1 (TAK1), a MAP3K family member, in cartilage using the collagen 2alpha promoter. These mice display chondrodysplasia characterized by neonatal-onset runting, delayed...

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PMID: 20392264
DOI: 10.1111/j.1749-6632.2009.05222.x

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