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Article

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2012

Omori Emily, Inagaki Maiko, Mishina Yuji, Matsumoto Kunihiro, Ninomiya-Tsuji Jun

Abstract excerpt

Dysregulation in cellular redox systems results in accumulation of reactive oxygen species (ROS), which are causally associated with a number of disease conditions. Transforming growth factor β-activated kinase 1 (TAK1) is a signaling intermediate of innate immune signaling pathways and is critically involved in the redox regulation in vivo. Ablation of TAK1 causes accumulation of ROS, resulting in epithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22331902
DOI: 10.1073/pnas.1116188109
PMCID: PMC3295251

Genes

TAB1
TAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.PMID 22331902Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

A mouse model for functional dissection of TAB1 O-GlcNAcylationSemantic proximity Read ↗

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.Semantic proximity Read ↗

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.Semantic proximity Read ↗

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.Semantic proximity Read ↗

Generation of a conditional mutant allele for Tab1 in mouse.Semantic proximity Read ↗

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.Semantic proximity Read ↗

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.Semantic proximity Read ↗

Roles for the IKK-Related Kinases TBK1 and IKKε in CancerSemantic proximity Read ↗

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.Semantic proximity Read ↗

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.Semantic proximity Read ↗

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.Semantic proximity Read ↗

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