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TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

13 Sept 2012

Abstract excerpt

TGF-β activated kinase 1 (TAK1) is a mediator of various cytokine signaling pathways. Germline deficiency of Tak1 causes multiple abnormalities, including dilated blood vessels at midgestation. However, the mechanisms by which TAK1 regulates vessel formation have not been elucidated. TAK1 binding proteins 1 and 2 (TAB1 and TAB2) are activators of TAK1, but their roles in embryonic TAK1 signaling have not been...

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PMID: 22972987
DOI: 10.1182/blood-2012-03-416198

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