Article
The TGF beta activated kinase TAK1 regulates vascular development in vivo.
Development (Cambridge, England) - 1 Apr 2006
Jadrich Joy L, O'Connor Michael B, Coucouvanis Electra
Abstract excerpt
TGFbeta activated kinase 1 (TAK1) is a MAPKKK that in cell culture systems has been shown to act downstream of a variety of signaling molecules, including TGFbeta. Its role during vertebrate development, however, has not been examined by true loss-of-function studies. In this report, we describe the phenotype of mouse embryos in which the Tak1 gene has been inactivated by a genetrap insertion. Tak1 mutant embryos...
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