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Article

Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping.

The American journal of tropical medicine and hygiene - 1 Aug 2008

Liu Shengfa, Mu Jianbing, Jiang Hongying, Su Xin-zhuan

Abstract excerpt

Studying drug resistance in Plasmodium falciparum requires accurate measurement of parasite response to a drug. Factors such as mixed infection of drug-resistant and -sensitive parasites can influence drug test outcome. Polymorphic DNA sequences are frequently used to detect mixed infections; infections with a single genotype or having a minor allele smaller than a subjectively selected cut-off value are often...

Topics

Animals
Antimalarials
Drug Resistance
Genotype
Inhibitory Concentration 50
Malaria, Falciparum
Microsatellite Repeats
Parasitic Sensitivity Tests
Plasmodium falciparum
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18689621
PMCID: PMC2680026

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