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Article

Critical Evaluation of Molecular Monitoring in Malaria Drug Efficacy Trials and Pitfalls of Length-Polymorphic Markers.

Antimicrobial agents and chemotherapy - 1 Jan 2017

Messerli Camilla, Hofmann Natalie E, Beck Hans-Peter, Felger Ingrid

Abstract excerpt

Estimation of drug efficacy in antimalarial drug trials requires parasite genotyping to distinguish new infections from treatment failures. When using length-polymorphic molecular markers, preferential amplification of short fragments can compromise detection of coinfections, potentially leading to misclassification of treatment outcome. We quantified minority clone detectability and competition among msp1, msp2,...

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Identifiers

PMID: 27821442
DOI: 10.1128/AAC.01500-16
PMCID: PMC5192142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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