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Article

Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes.

The Journal of infectious diseases - 15 Dec 2013

Taylor Steve M, Parobek Christian M, Aragam Nash, Ngasala Billy E, Mårtensson Andreas, Meshnick Steven R, Juliano Jonathan J

Abstract excerpt

Molecular surveillance for drug-resistant malaria parasites requires reliable, timely, and scalable methods. These data may be efficiently produced by genotyping parasite populations using second-generation sequencing (SGS). We designed and validated a SGS protocol to quantify mutant allele frequencies in the Plasmodium falciparum genes dhfr and dhps in mixed isolates. We applied this new protocol to field...

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Identifiers

PMID: 23908494
DOI: 10.1093/infdis/jit392
PMCID: PMC3836461

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