Article
Nonlinear mixed-effects modelling of in vitro drug susceptibility and molecular correlates of multidrug resistant Plasmodium falciparum.
PloS one - 1 Jan 2013
Simpson Julie A, Jamsen Kris M, Anderson Tim J C, Zaloumis Sophie, Nair Shalini, Woodrow Charles, White Nicholas J, Nosten Francois, Price Ric N
Abstract excerpt
The analysis of in vitro anti-malarial drug susceptibility testing is vulnerable to the effects of different statistical approaches and selection biases. These confounding factors were assessed with respect to pfmdr1 gene mutation and amplification in 490 clinical isolates. Two statistical approaches for estimating the drug concentration associated with 50% effect (EC50 ) were compared: the commonly used standard...
Topics
- Antimalarials
- Artemisinins
- Artesunate
- Chloroquine
- Ethanolamines
- Fluorenes
- Lumefantrine
- Mefloquine
- Models, Statistical
- Multidrug Resistance-Associated Proteins