Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum.

EBioMedicine - 1 May 2024

Maiga Hamma, Morrison Robert D, Duffy Patrick E

Abstract excerpt

BACKGROUND: Anti-malarial drug resistance in Plasmodium falciparum is a major public health problem in malaria-endemic regions. Although various technical improvements in sequencing methods have been introduced to identify SNPs, the conventional approach with current tools does not discriminate mixed infections, and thus can be improved for more sensitive surveillance of anti-malarial resistance to better inform...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antimalarials
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Plasmodium falciparum

Share to Protozoan Proteins

Share to Sequence Analysis, DNA

Share to Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 38636200
DOI: 10.1016/j.ebiom.2024.105115
PMCID: PMC11031737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum.PMID 38636200Read ↗

Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes.Semantic proximity Read ↗

Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing dataSemantic proximity Read ↗

Proof of concept: Malaria rapid diagnostic tests and massively parallel sequencing for surveillance of molecular markers of antimalarial resistance in Bissau, Guinea-Bissau during 2014-2017Semantic proximity Read ↗

PHARE: a bioinformatics pipeline for compositional profiling of multiclonal Plasmodium falciparum infections from long-read Nanopore sequencing data.Semantic proximity Read ↗

Rapid profiling of Plasmodium parasites from genome sequences to assist malaria controlSemantic proximity Read ↗

Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials?Semantic proximity Read ↗

The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malariaSemantic proximity Read ↗

A Statistical Method to Estimate the Population-Level Frequencies of <i>Plasmodium falciparum</i> Haplotypes with <i>Pfhrp</i> 2/3 Deletions in the Presence of Mixed-Clone InfectionsSemantic proximity Read ↗

A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes.Semantic proximity Read ↗

Estimating SNP proportions in populations of malaria parasites by sequencing: validation and applications.Semantic proximity Read ↗

Genotyping methods to distinguish Plasmodium falciparum recrudescence from new infection for the assessment of antimalarial drug efficacy: an observational, single-centre, comparison study.Semantic proximity Read ↗

Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.