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Article

Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.

The American journal of tropical medicine and hygiene - 1 Jun 2015

Huijben Silvie, Chan Brian H K, Read Andrew F

Abstract excerpt

Resistant malaria parasites are frequently found in mixed infections with drug-sensitive parasites. Particularly early in the evolutionary process, the frequency of these resistant mutants can be extremely low and below the level of molecular detection. We tested whether the rarity of resistance in infections impacted the health outcomes of treatment failure and the potential for onward transmission of...

Topics

Animals
Antimalarials
Drug Resistance
Female
Genotype
Malaria
Mice, Inbred C57BL
Plasmodium chabaudi
Polymerase Chain Reaction
Treatment Failure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25940195
DOI: 10.4269/ajtmh.15-0036
PMCID: PMC4458828

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