Greater Endothelial Activation, Weibel‐Palade Body Release and Host Inflammatory Response toPlasmodium vivax,Compared withPlasmodium falciparum: A Prospective Study in Papua, Indonesia

Abstract excerpt

Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count,...

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