Article
Hypercholesterolemia promotes leukocyte-dependent platelet adhesion in murine postcapillary venules.
Microcirculation (New York, N.Y. : 1994) - 1 Jan 2000
Tailor Anitaben, Granger D Neil
Abstract excerpt
OBJECTIVE: Leukocyte-platelet aggregates form in blood during the development of cardiovascular diseases, including atherosclerosis. The study determined whether leukocytes contribute to the platelet adhesion induced by hypercholesterolemia in postcapillary venules. METHODS: Wild-type (WT) C57Bl/6 or CD18-deficient (CD18-/-) mice were placed on a normal (ND) or high-cholesterol (HC) diet for 2 weeks. Platelets...
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